The research of the group led by Prof. Matthias Ernst in the Laboratory of Physical Chemistry, Department of Chemistry and Applied Biosciences at ETH Zürich, works on method development in high-resolution solid-state NMR of biomolecules. We are seeking applications for a
PhD position - Method development in solid-state NMR
We are working on the development of new experiments for high-resolution solid-state NMR of biomolecules. The emphasis of the work will be on experiments under fast sample rotation conditions where new experimental schemes are required. The work involves developing new theoretical concepts to better understand time-dependent Hamiltonians, computer simulations of spin systems, and experimental work to implement and test new methods on model systems and small proteins.
The successful candidate
will work on theoretical concepts to describe solid-state NMR experiments, as the detailed understanding of the spin dynamics is an essential step to develop improved or new experiments. The analytical calculations will be then verified through exact numerical simulations of spin systems. Finally, the new experiments will be implemented on commercial spectrometers first using small model systems and then applied to more complex biological samples. The interplay between theory, numerical simulations and experimental work is essential for successful method development in NMR and a strong interest in all three areas is extremely important. This work has been a longstanding collaboration with Prof. Beat H. Meier.
Prerequisites are a Master in Physics, Interdisciplinary Sciences, Chemistry, or related areas. Motivation to work independently in a multidisciplinary team and a strong interest in theory, experimental work, and computer simulations are required. Previous experience in magnetic resonance is a plus but not required.