Your job alert was successfully created.
University of Antwerp
Doctoral Grant (BOF), AT-DNA sensing & autophagy
University of Antwerp
The University of Antwerp (Universiteit Antwerpen) is characterised by its high standards in education, internationally competitive research and entrepreneurial approach.
Visit employer page
JOB DETAILS
Published: 14 days ago
Application deadline: Aug 12
Location: Antwerpen, Belgium
Please mention that you found this job on Academic Positions when applying.
SHARE THIS JOB

Doctoral Grant (BOF), AT-DNA sensing & autophagy

The Faculty of Medicine and Health Sciences is seeking to fill a full-time (100%) vacancy in the Vaccine and Infectious Disease Institute for a

Doctoral Grant by the University Research Fund (BOF) in the area of “AT-DNA sensing & autophagy as major features in the development of chickenpox-associated neurological complications”

Varicella-zoster virus (VZV) causes chickenpox in children and can cause encephalitis, cerebellitis or stroke during both the acute and subacute phases of chickenpox. The pathophysiology underlying all of these central nervous system VZV complications remains largely unknown so far.

We previously showed that mutations in RNA polymerase III (POL III) cause a defect in VZV sensing (via AT-DNA “recognition”) in blood cells and consequently cause a reduced control of VZV proliferation. In this project, we aim to show that following primary VZV infection, glial cells, which are immune-responsive cells in the central nervous system, recognize VZV and subsequently produce protective cytokines. Moreover, we will assess whether mutations in AT-DNA sensor POL III in children with encephalitis, cerebellitis or stroke/vasculitis due to chickenpox have a defective recognition of VZV and subsequently increased VZV proliferation in central neurons. We will do this by differentiating induced pluripotent stem cells (iPSC) from patients and controls into neurons and glial cells, and subsequently infecting these with VZV. In addition, preliminary data from our labs and others have shown that autophagy might be involved in cellular VZV dynamics. In this project, we also aim to further address this potential pathogenic route by experimentally inhibiting autophagy in iPSC-derived neurons from healthy controls and measuring the subsequent effects on VZV dynamics.

Experimentally, this translational project will therefore use a wide array of techniques, including the development and maintenance of iPSC-derived neuronal cell cultures, VZV production and infection monitoring, ELISA, western blotting, whole exome sequencing and autophagy modulation.

Job description

  • You prepare a doctoral thesis in the field of Medical Sciences.
  • You publish scientific articles related to the research project of the assignment.
  • You contribute to teaching and research in the Faculty of Medicine and Health Sciences.

Profile and requirements

  • You hold a master degree in Biology, Biochemistry, Biomedical Sciences, Pharmaceutical Sciences, Bio-Engineering, Veterinary Sciences or Medicine.
  • You can submit outstanding academic results.
  • Students in the final year of their degree can also apply.
  • Foreign candidates are encouraged to apply.
  • Your academic qualities comply with the requirements stipulated in the university’s policy.
  • You are quality-oriented, conscientious, creative and cooperative.
  • You are highly motivated, flexible, capable to manage stress and communicate properly (both in English and Dutch).
  • Experience with culture and differentiation of human embryonic stem cells and/or induced pluripotent stem cells and/or viral infections of cell cultures is recommended, but not explicitly required.

We offer

  • a doctoral scholarship for a period of two years, with the possibility of renewal for a further two-year period after positive evaluation;
  • the start date of scholarship will be October 1st, November 1st or December 1st 2018 or January 1st 2019;
  • a gross monthly grant ranging from € 2.324,20 to € 2.469,08;
  • a dynamic and stimulating work environment.

How to apply?

  • Applications may only be submitted online until the closing date August 12th 2018 and should include a copy of your CV and a cover letter.
  • A pre-selection will be made from amongst the submitted applications.
  • The remainder of the selection procedure is specific to the position and will be determined by the selection panel.
  • The interviews of the candidates, preselected by a selection panel, will take place from August 20th until September 14th 2018.
  • More information about the application form can be obtained from vacatures@uantwerpen.be. For questions about the profile and the description of duties, please contact prof. Benson Ogunjimi (benson.ogunjimi@uantwerp.be).

The University of Antwerp is a family friendly organization, with a focus on equal opportunities and diversity. Our HR-policy for researchers was awarded by the European Commission with the quality label HR Excellence in research.

We support the Science4Refugees initiative and encourage asylum-seeking, refugee scientists and researchers to apply for a job at the University of Antwerp.

Continue reading

81 JOBS FROM THIS EMPLOYER

University of Antwerp
University of Antwerp
Location: Antwerpen, Belgium | Closing on Aug 10
Radiopharmacist - 2018BAPFGGWEF272
The Molecular Imaging Center Antwerp (MICA) of the Faculty of Medicine and Health Sciences of Antwerp is seeking to fill the following full-time (100 %) vacancy Radiopharmacist The Molecular Imaging Center Antwerp (MICA) is a dynamic team focusing on preclinical and...
University of Antwerp
University of Antwerp
Location: Antwerpen, Belgium | Closing on Aug 15
Tenured academic staff, Fundamental rights and liberties - 2018ZAPFRECHEX270
The Faculty of Law is seeking to fill the following part-time (10 %) vacancy Tenured academic staff in the area of ‘Fundamental rights and liberties’ (replacement) Job description You will lecture ‘Fundamental rights and liberties’ (45 contact...
University of Antwerp
University of Antwerp
Location: Antwerpen, Belgium | Closing on Sep 02
Tenured academic staff, Organic chemistry - 2018ZAPFWETEX268
The Faculty of Sciences is seeking to fill the following full-time vacancy in the Department of Chemistry Tenured academic staff in the area of organic chemistry Job description You will be teaching organic chemistry for a total of 100 hours of theoretical courses at...
University of Antwerp
University of Antwerp
Location: Antwerpen, Belgium | Closing on Sep 02
Tenured academic staff, Gas phase photocatalysis en photoelectrochemistry - 2018ZAPFWETEX269
The Faculty of Science is seeking to fill the following part-time (80%) vacancy in the Department of Bioscience Engineering Tenured academic staff in the area of Gas phase photocatalysis en photoelectrochemistry Job description The assignment has a structural...